We had a mishmash of wireless T/R's in my last band. The bass player and I both owned stereo IEM transmitters, all four of us had belt-mounted receivers/IEMs, and would hard-pan each to right or left, so that each of us got our own customized mono mix. Then, we had wireless TXs (a mix of both VHF and UHF), one for Jeff's bass, Jeff's headset mic, JP's Guitar, JP's headset mic, Wayne's headset mic (no wireless required for drums) and my fiddle and tenor (I used a wired mic on my keyboard stack).
It all worked, and weighed a HELL of a lot less than floor wedges, and amps, and one-mix-fits-all, and...